You are experiencing an allergic reaction, seek immediate medical attention. Applies to fluoxetine: oral capsule, oral capsule delayed release, oral solution, oral syrup, oral tablet I have had a skin rash that has evolved and grown over the past 15 months or so. It started out as a dry skin, scaly, and painful patch between the fingers of my left hand. Moreover, a cross-sensitivity has been reported when skin rash developed after both paroxetine and sertraline medication. Since these substances are structurally different, one interpretation is that the skin can react to an SSRI-induced increase in serotonin concentrations. Applies to fluoxetine: compounding powder, oral capsule, oral delayed release capsule, oral solution, oral tablet General The most commonly reported side effects included insomnia , asthenia, and headache. The best intervention for a potentially life-threatening drug rash can happen before you choose a psychotropic. Carefully evaluating your patient’s risk for an adverse cutaneous drug reaction (ACDR) will guide safer prescribing. Case presentation. A 46-year-old man consulted his doctor due to symptoms of depression. He did not suffer from any allergy but drinking red wine caused vasomotor rhinitis. In another case of rash after initiation of fluoxetine, it was part of a severe ‘serum sickness’ like condition and rash was associated with fever and joint pain [3]. Although a skin test with fluoxetine could have reasonably proved the causal association between rash and fluoxetine, the same could not be done because of patient’s preferences. severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. If you get a skin rash while taking this medication, consult your doctor as soon as possible. Bleeding: Fluoxetine may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions.